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BITS Pilani Institutional Repository
Browsing by Author Taliyan, Rajeev
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Showing results 46 to 65 of 96
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Issue Date
Title
Author(s)
2016-11
Histone deacetylase inhibitors: Future therapeutics for insulin resistance and type 2 diabetes
Taliyan, Rajeev
2021-09
Human Serum Albumin as Multifunctional Nanocarrier for Cancer Therapy
Taliyan, Rajeev
2024-11
Immunological challenges and opportunities in glioblastoma multiforme: A comprehensive view from immune system lens
Singhvi, Gautam
;
Taliyan, Rajeev
2024-08
Label-free GaN HEMT-based biosensing platform for interferon-γ detection
Taliyan, Rajeev
2021-04
Lentiviral mediated gene delivery as an effective therapeutic approach for Parkinson disease
Taliyan, Rajeev
2024
Meander-gated dual cap gan hemt-based portable noninvasive covid-19 detection platform
Taliyan, Rajeev
2023-07
Mechanistic Insights of Meglitinides Drug Repurposing and Delivery to Brain for Metabolic Syndrome Linked Neurodegenerative Disease
Taliyan, Rajeev
2025-01
Millions of people worldwide are negatively impacted by a diverse range of brain conditions known as neurodegenerative diseases. The work reports a GaN HEMT-based biosensing system for the early detection and monitoring of neurodegenerative disease biomarkers in clinically relevant concentration ranges. The developed system offers a high sensitivity of 19.40 µA/pg/ml, 0.52 mA/pg/ml, 0.69 mA/ng/ml, 0.13 mA/pg/ml, 23.66 µA/pg/ml, and 23.85 µA/pg/ml for the detection of UCH-L1, GFAP, S100B, IL-6, Aβ, and IFN-γ respectively. The proposed biofunctionalization assay has an excellent specificity and selectivity, signal-to-noise ratio of 1:16, 1:23, and 1:38 for UCH-L1, GFAP, and S100B detection respectively with a LoD of 0.06 fg/ml. The platform has good repeatability with an average sensitivity of 19.41 µA/pg/ml, 0.524 mA/pg/ml, and 0.704 mA/ng/ml for UCH-L1, GFAP, and S100B detection respectively. The sensors have a very good shelf-life for a storage time of 35 days with reductions of 1.39 %, 1.72 %, and 2.05 % in sensor response and 2.88 %, 2.76 %, and 2.96 % in sensitivity for UCH-L1, GFAP, and S100B respectively. The coefficient of variation (CV) values for conventional and meander-gated GaN HEMT biosensors were found to be ∼0.038 and ∼0.026 respectively. A slight variation of ∼4.41 % in sensor response when the sensor was reused clearly demonstrates the sensor’s reusability. A very high resolution with detection capability in the ultra-low concentration of fg/ml with good linearity and quantifiable sensor response which is a key requirement for early-stage detection of diseases has been observed for sensor design with source-to-drain distance () of 10 µm. Thus, the platform capability and suitability for early detection and prognosis of neurodegenerative disease detection and monitoring have been demonstrated. Further, the system can be imperative in patient screening in clinical, sports, and warfare for CT or MRI scan requirements.
Taliyan, Rajeev
2022-03
Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer’s disease
Taliyan, Rajeev
;
Singhvi, Gautam
2023
Nanoperfumes as a fragrance product
Taliyan, Rajeev
2025-01
Neurodegenerative diseases early detection and monitoring system for point-of-care applications
Taliyan, Rajeev
2015-08
Neuroprotective effect of hydroxy safflor yellow A against cerebral ischemia-reperfusion injury in rats: putative role of mPTP
Taliyan, Rajeev
2022-02
Neuroprotective Effect of Lentivirus-Mediated FGF21 Gene Delivery in Experimental Alzheimer’s Disease is Augmented when Concerted with Rapamycin
Taliyan, Rajeev
2021-07
Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson’s Disease
Taliyan, Rajeev
2021-04
Neuroprotective efficacy of co-encapsulated rosiglitazone and vorinostat nanoparticle on streptozotocin induced mice model of Alzheimer disease
Taliyan, Rajeev
;
Chitkara, Deepak
2024-12
Neuroprotective potential of Epigenetic modulators, its regulation and therapeutic approaches for the management of Parkinson's disease
Taliyan, Rajeev
2014-10
Neuroprotective role of Indirubin-3′-monoxime, a GSKβ inhibitor in high fat diet induced cognitive impairment in mice
Taliyan, Rajeev
2021-04
NEXT Neuroprotective Efficacy of Co-Encapsulated Rosiglitazone and Vorinostat Nanoparticle on Streptozotocin Induced Mice Model of Alzheimer Disease
Chitkara, Deepak
;
Taliyan, Rajeev
2024-06
Novel gene therapy approaches for targeting neurodegenerative disorders: focusing on delivering neurotrophic genes
Taliyan, Rajeev
2021-11
A novel UPLC–MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats
Taliyan, Rajeev