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Browsing by Author Taliyan, Rajeev

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Issue DateTitleAuthor(s)
2016-11Histone deacetylase inhibitors: Future therapeutics for insulin resistance and type 2 diabetesTaliyan, Rajeev
2021-09Human Serum Albumin as Multifunctional Nanocarrier for Cancer TherapyTaliyan, Rajeev
2024-11Immunological challenges and opportunities in glioblastoma multiforme: A comprehensive view from immune system lensSinghvi, Gautam; Taliyan, Rajeev
2024-08Label-free GaN HEMT-based biosensing platform for interferon-γ detectionTaliyan, Rajeev
2021-04Lentiviral mediated gene delivery as an effective therapeutic approach for Parkinson diseaseTaliyan, Rajeev
2024Meander-gated dual cap gan hemt-based portable noninvasive covid-19 detection platformTaliyan, Rajeev
2023-07Mechanistic Insights of Meglitinides Drug Repurposing and Delivery to Brain for Metabolic Syndrome Linked Neurodegenerative DiseaseTaliyan, Rajeev
2025-01Millions of people worldwide are negatively impacted by a diverse range of brain conditions known as neurodegenerative diseases. The work reports a GaN HEMT-based biosensing system for the early detection and monitoring of neurodegenerative disease biomarkers in clinically relevant concentration ranges. The developed system offers a high sensitivity of 19.40 µA/pg/ml, 0.52 mA/pg/ml, 0.69 mA/ng/ml, 0.13 mA/pg/ml, 23.66 µA/pg/ml, and 23.85 µA/pg/ml for the detection of UCH-L1, GFAP, S100B, IL-6, Aβ, and IFN-γ respectively. The proposed biofunctionalization assay has an excellent specificity and selectivity, signal-to-noise ratio of 1:16, 1:23, and 1:38 for UCH-L1, GFAP, and S100B detection respectively with a LoD of 0.06 fg/ml. The platform has good repeatability with an average sensitivity of 19.41 µA/pg/ml, 0.524 mA/pg/ml, and 0.704 mA/ng/ml for UCH-L1, GFAP, and S100B detection respectively. The sensors have a very good shelf-life for a storage time of 35 days with reductions of 1.39 %, 1.72 %, and 2.05 % in sensor response and 2.88 %, 2.76 %, and 2.96 % in sensitivity for UCH-L1, GFAP, and S100B respectively. The coefficient of variation (CV) values for conventional and meander-gated GaN HEMT biosensors were found to be ∼0.038 and ∼0.026 respectively. A slight variation of ∼4.41 % in sensor response when the sensor was reused clearly demonstrates the sensor’s reusability. A very high resolution with detection capability in the ultra-low concentration of fg/ml with good linearity and quantifiable sensor response which is a key requirement for early-stage detection of diseases has been observed for sensor design with source-to-drain distance () of 10 µm. Thus, the platform capability and suitability for early detection and prognosis of neurodegenerative disease detection and monitoring have been demonstrated. Further, the system can be imperative in patient screening in clinical, sports, and warfare for CT or MRI scan requirements.Taliyan, Rajeev
2022-03Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer’s diseaseTaliyan, Rajeev; Singhvi, Gautam
2023Nanoperfumes as a fragrance productTaliyan, Rajeev
2025-01Neurodegenerative diseases early detection and monitoring system for point-of-care applicationsTaliyan, Rajeev
2015-08Neuroprotective effect of hydroxy safflor yellow A against cerebral ischemia-reperfusion injury in rats: putative role of mPTPTaliyan, Rajeev
2022-02Neuroprotective Effect of Lentivirus-Mediated FGF21 Gene Delivery in Experimental Alzheimer’s Disease is Augmented when Concerted with RapamycinTaliyan, Rajeev
2021-07Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson’s DiseaseTaliyan, Rajeev
2021-04Neuroprotective efficacy of co-encapsulated rosiglitazone and vorinostat nanoparticle on streptozotocin induced mice model of Alzheimer diseaseTaliyan, Rajeev; Chitkara, Deepak
2024-12Neuroprotective potential of Epigenetic modulators, its regulation and therapeutic approaches for the management of Parkinson's diseaseTaliyan, Rajeev
2014-10Neuroprotective role of Indirubin-3′-monoxime, a GSKβ inhibitor in high fat diet induced cognitive impairment in miceTaliyan, Rajeev
2021-04NEXT Neuroprotective Efficacy of Co-Encapsulated Rosiglitazone and Vorinostat Nanoparticle on Streptozotocin Induced Mice Model of Alzheimer DiseaseChitkara, Deepak; Taliyan, Rajeev
2024-06Novel gene therapy approaches for targeting neurodegenerative disorders: focusing on delivering neurotrophic genesTaliyan, Rajeev
2021-11A novel UPLC–MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic ratsTaliyan, Rajeev