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BITS Pilani Institutional Repository
Browsing by Subject Biological activity
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Showing results 1 to 3 of 3
Issue Date
Title
Author(s)
2023
Design synthesis and biological activity of novel nitrogen containing heterocyclic compounds as antileishmanial and antitubercular agents
Adinarayana, Nandikolla
2020
Leishmaniasis is the most widespread pathogenic disease in several countries. Currently, no effective vaccines are available, and the control of Leishmaniasis primarily relies on decade-old chemotherapy. The treatment for the Leishmaniasis is not up to the mark. Current therapy for Leishmaniasis is ancient and requires hospitalization for the administration. These medications are also highly toxic and resistant. β-carboline, a natural indole containing alkaloid, holds a vital position in the field of medicinal chemistry with a diversified pharmacological action. The current review focuses mainly on the anti-leishmanial effects of β-carboline analogs and their synthetic strategies, structural activity relationship studies (SAR). The past ten years alterations unveiled by β-carboline analogs present in phytoconstituents and various derivatives of synthesized analogs with the mechanism of action were briefly shortlisted and illustrated
Murugesan, Sankaranarayanan
2023-07
A multifaceted scaffold for building bioactive compounds: phenothiazine
Jain, Ankit