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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mahesh, R. | - |
dc.date.accessioned | 2023-11-18T06:25:21Z | - |
dc.date.available | 2023-11-18T06:25:21Z | - |
dc.date.issued | 2004-10 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0960894X04009618 | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13161 | - |
dc.description.abstract | A series of novel 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile 6 were prepared by microwave irradiation and conventional heating. The intermediate, 2-oxo-1,2-dihydro-1,8-naphthyridine-3-carbonitrile 3, was prepared from 2-aminonicotinaldehyde 1 and ethyl cyanoacetate 2 in the presence of piperidine under solvent free condition. The synthesized compounds were evaluated for 5-HT3 antagonisms in longitudinal muscle-myenteric plexus (LMMP) preparation from Guinea pig ileum against 5-HT3 agonist, 2-methyl-5-HT. Among the compounds tested, 2-(4-allylpiperazin-1-yl)-1,8-naphthyridine-3-carbonitrile 6d showed most favorable 5-HT3 receptor antagonism in the Guinea pig ileum. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Pharmacy | en_US |
dc.subject | Microwaves | en_US |
dc.subject | Antagonists | en_US |
dc.title | Microwave assisted synthesis of 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile as a new class of serotonin 5-HT3 receptor antagonists | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Pharmacy |
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