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Title: | Etazolate, a phosphodiesterase-4 enzyme inhibitor produces antidepressant-like effects by blocking the behavioral, biochemical, neurobiological deficits and histological abnormalities in hippocampus region caused by olfactory bulbectomy |
Authors: | Mahesh, R. |
Keywords: | Olfactory bulbectomy (OBX) Phosphodiesterase-4 Etazolate |
Issue Date: | Aug-2014 |
Publisher: | Springer |
Abstract: | Olfactory bulbectomy (OBX) is a widely used model for antidepressant screening and known to induce neurodegeneration in several brain areas. Our earlier studies demonstrated that etazolate produced antidepressant-like effects in behavioral despair models of depression; however, the potential role of etazolate on behavior and morphological changes in the hippocampus region along with its underlying mechanism(s) following OBX has not been adequately addressed. |
URI: | https://link.springer.com/article/10.1007/s00213-014-3705-0 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13168 |
Appears in Collections: | Department of Pharmacy |
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