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http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13179| Title: | Pharmacophore Based Synthesis of 3-Chloroquinoxaline-2-carboxamides as Serotonin3 (5-HT3) Receptor Antagonist |
| Authors: | Mahesh, R. |
| Keywords: | Pharmacy Pharmacophore 5-HT3 receptor antagonist |
| Issue Date: | 2004 |
| Publisher: | The Pharmaceutical Society of Japan |
| Abstract: | A series of 3-chloroquinoxaline-2-carboxamides were designed and prepared by the condensation of 3-chloro-2-quinoxaloylchloride with appropriate Mannich bases of the p-aminophenol in the microwave environment. The synthesized compounds were evaluated for serotonin3 (5-HT3) receptor antagonistic activities in longitudinal muscle-myenteric plexus (LMMP) preparation from guinea pig ileum against the 5-HT3 agonist, 2-methyl-5-HT. Compound 3g exhibited comparable 5-HT3 antagonistic activity (pA2 6.4) to that of standard antagonist Ondansetron (pA2 6.9), while the other compounds exhibited mild to moderate 5-HT3 antagonistic activities. |
| URI: | https://www.jstage.jst.go.jp/article/bpb/27/9/27_9_1403/_article/-char/ja/ http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13179 |
| Appears in Collections: | Department of Pharmacy |
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