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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13179
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dc.contributor.authorMahesh, R.-
dc.date.accessioned2023-11-20T07:05:03Z-
dc.date.available2023-11-20T07:05:03Z-
dc.date.issued2004-
dc.identifier.urihttps://www.jstage.jst.go.jp/article/bpb/27/9/27_9_1403/_article/-char/ja/-
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13179-
dc.description.abstractA series of 3-chloroquinoxaline-2-carboxamides were designed and prepared by the condensation of 3-chloro-2-quinoxaloylchloride with appropriate Mannich bases of the p-aminophenol in the microwave environment. The synthesized compounds were evaluated for serotonin3 (5-HT3) receptor antagonistic activities in longitudinal muscle-myenteric plexus (LMMP) preparation from guinea pig ileum against the 5-HT3 agonist, 2-methyl-5-HT. Compound 3g exhibited comparable 5-HT3 antagonistic activity (pA2 6.4) to that of standard antagonist Ondansetron (pA2 6.9), while the other compounds exhibited mild to moderate 5-HT3 antagonistic activities.en_US
dc.language.isoenen_US
dc.publisherThe Pharmaceutical Society of Japanen_US
dc.subjectPharmacyen_US
dc.subjectPharmacophoreen_US
dc.subject5-HT3 receptor antagonisten_US
dc.titlePharmacophore Based Synthesis of 3-Chloroquinoxaline-2-carboxamides as Serotonin3 (5-HT3) Receptor Antagonisten_US
dc.typeArticleen_US
Appears in Collections:Department of Pharmacy

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