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Title: | Effect of anti-depressants on neuro-behavioural consequences following impact accelerated traumatic brain injury in rats |
Authors: | Mahesh, R. |
Keywords: | Pharmacy Traumatic brain injury (TBI) Anti-depressants |
Issue Date: | May-2010 |
Publisher: | NISCAIR |
Abstract: | Disruption of normal neuronal networks and neurotransmitters like serotonin and norepinephrine levels in post traumatic brain injury (TBI) are observed to be the primary causative agent for depression/anxiety. This communication reports the efficacy of various classes' anti-depressants in the treatment of depression/anxiety following TBI in rats. Chronic treatment with anti-depressants (escitalopram and venlafaxine) leads to improvement in the depressive/anxiogenic-like behaviour in the TBI rat and corroborates the notion of the involvement of serotonin and norepinephrine in the behavioural consequences of post-TBI. Chronic treatments with escitalopram and venlafaxine significantly reversed the effect of TBI as compared to vehicle-treated TBI group. The results showed a quantitative battery of neuro-behavioural functional assessments that correlates with neuronal damage following traumatic brain injury |
URI: | https://nopr.niscpr.res.in/bitstream/123456789/8483/1/IJEB%2048%285%29%20466-473.pdf http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13191 |
Appears in Collections: | Department of Pharmacy |
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