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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mahesh, R. | - |
dc.date.accessioned | 2023-11-20T10:53:16Z | - |
dc.date.available | 2023-11-20T10:53:16Z | - |
dc.date.issued | 2010-05 | - |
dc.identifier.uri | https://nopr.niscpr.res.in/bitstream/123456789/8483/1/IJEB%2048%285%29%20466-473.pdf | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13191 | - |
dc.description.abstract | Disruption of normal neuronal networks and neurotransmitters like serotonin and norepinephrine levels in post traumatic brain injury (TBI) are observed to be the primary causative agent for depression/anxiety. This communication reports the efficacy of various classes' anti-depressants in the treatment of depression/anxiety following TBI in rats. Chronic treatment with anti-depressants (escitalopram and venlafaxine) leads to improvement in the depressive/anxiogenic-like behaviour in the TBI rat and corroborates the notion of the involvement of serotonin and norepinephrine in the behavioural consequences of post-TBI. Chronic treatments with escitalopram and venlafaxine significantly reversed the effect of TBI as compared to vehicle-treated TBI group. The results showed a quantitative battery of neuro-behavioural functional assessments that correlates with neuronal damage following traumatic brain injury | en_US |
dc.language.iso | en | en_US |
dc.publisher | NISCAIR | en_US |
dc.subject | Pharmacy | en_US |
dc.subject | Traumatic brain injury (TBI) | en_US |
dc.subject | Anti-depressants | en_US |
dc.title | Effect of anti-depressants on neuro-behavioural consequences following impact accelerated traumatic brain injury in rats | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Pharmacy |
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