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http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/13200| Title: | Antidepressant-like activity of (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a), a novel 5-HT3 receptor antagonist: An investigation in behaviour-based rodent models of depression |
| Authors: | Mahesh, R. |
| Keywords: | Pharmacy (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone 4a 5-HT3 receptor antagonist Depression Forced swim test (FST) Olfactory bulbectomy (OBX) |
| Issue Date: | Sep-2012 |
| Publisher: | Wolters Kluwer |
| Abstract: | The present study was designed to investigate the antidepressant potential of (4-phenylpiperazin-1-yl) (quinoxalin-3-yl) methanone (4a), a novel 5-HT3 receptor antagonist, with an optimal log P (2.84) and pA2 value (7.3) greater than ondansetron (6.9) using rodent behavioural models of depression. |
| URI: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480784/ http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13200 |
| Appears in Collections: | Department of Pharmacy |
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