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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mahesh, R. | - |
dc.date.accessioned | 2023-11-21T05:06:36Z | - |
dc.date.available | 2023-11-21T05:06:36Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.3109/14756366.2010.543419 | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13201 | - |
dc.description.abstract | A series of quinoxalin-2-carboxamides were designed as per the pharmacophoric requirements of 5-HT3 receptor antagonists and synthesized by condensing the carboxylic group of quinoxalin-2-carboxylic acid with various amines in the presence of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 1-hydroxybenzotriazole. The structures of the synthesized compounds were confirmed by physical and spectroscopic data. The carboxamides were evaluated for their 5-HT3 receptor antagonisms in longitudinal muscle-myenteric plexus preparation from guinea pig ileum against 5-HT3 agonist, 2-methy-5-HT. All the synthesized compounds showed 5-HT3 receptor antagonism, (4-benzylpiperazin-1-yl)(quinoxalin-2-yl)methanone was the most potent compound among this series. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.subject | Pharmacy | en_US |
dc.subject | Quinoxalin-2-carboxamides | en_US |
dc.subject | Serotonin system | en_US |
dc.subject | 5-HT3 receptor antagonists | en_US |
dc.subject | Quinoxaline | en_US |
dc.title | Quinoxalin-2-carboxamides: synthesis and pharmacological evaluation as serotonin type-3 (5-HT3) receptor antagonists | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Pharmacy |
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