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Title: | Quinoxalin-2-carboxamides: synthesis and pharmacological evaluation as serotonin type-3 (5-HT3) receptor antagonists |
Authors: | Mahesh, R. |
Keywords: | Pharmacy Quinoxalin-2-carboxamides Serotonin system 5-HT3 receptor antagonists Quinoxaline |
Issue Date: | Jan-2011 |
Publisher: | Taylor & Francis |
Abstract: | A series of quinoxalin-2-carboxamides were designed as per the pharmacophoric requirements of 5-HT3 receptor antagonists and synthesized by condensing the carboxylic group of quinoxalin-2-carboxylic acid with various amines in the presence of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 1-hydroxybenzotriazole. The structures of the synthesized compounds were confirmed by physical and spectroscopic data. The carboxamides were evaluated for their 5-HT3 receptor antagonisms in longitudinal muscle-myenteric plexus preparation from guinea pig ileum against 5-HT3 agonist, 2-methy-5-HT. All the synthesized compounds showed 5-HT3 receptor antagonism, (4-benzylpiperazin-1-yl)(quinoxalin-2-yl)methanone was the most potent compound among this series. |
URI: | https://www.tandfonline.com/doi/full/10.3109/14756366.2010.543419 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13201 |
Appears in Collections: | Department of Pharmacy |
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