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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mahesh, R. | - |
dc.date.accessioned | 2023-11-22T09:05:24Z | - |
dc.date.available | 2023-11-22T09:05:24Z | - |
dc.date.issued | 2016-09 | - |
dc.identifier.uri | https://www.degruyter.com/document/doi/10.1515/jbcpp-2016-0057/html | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13217 | - |
dc.description.abstract | Several preclinical studies have shown that serotonergic 5-HT3 receptor antagonists play an important role in the management of neuropsychiatric disorders, such as depression and anxiety. In the present study the compound ā6nā (N-n-propyl-3-ethoxyquinoxaline-2-carboxamide), a novel 5-HT3 receptor antagonist with an optimal log P (2.52) and pA2 (7.6) value was screened for its neuro-pharmacological potential in chronic rodent models of depression and anxiety named traumatic brain injury (TBI). | en_US |
dc.language.iso | en | en_US |
dc.publisher | De Gruyter | en_US |
dc.subject | Pharmacy | en_US |
dc.subject | 5-HT3 receptor antagonist | en_US |
dc.subject | Brain-derived neurotrophic factor (BDNF) | en_US |
dc.subject | Depression | en_US |
dc.subject | Serotonin system | en_US |
dc.subject | Traumatic brain injury (TBI) | en_US |
dc.title | Neuropharmacological and neurochemical evaluation of N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n): a novel serotonergic 5-HT3 receptor antagonist for co-morbid antidepressant- and anxiolytic-like potential using traumatic brain injury model in rats | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Pharmacy |
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