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Title: | Neuropharmacological and neurochemical evaluation of N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n): a novel serotonergic 5-HT3 receptor antagonist for co-morbid antidepressant- and anxiolytic-like potential using traumatic brain injury model in rats |
Authors: | Mahesh, R. |
Keywords: | Pharmacy Neuropharmacological Neurochemical Traumatic brain injury (TBI) |
Issue Date: | 2016 |
Publisher: | De Gruyter |
Abstract: | Several preclinical studies have shown that serotonergic 5-HT3 receptor antagonists play an important role in the management of neuropsychiatric disorders, such as depression and anxiety. In the present study the compound ā6nā (N-n-propyl-3-ethoxyquinoxaline-2-carboxamide), a novel 5-HT3 receptor antagonist with an optimal log P (2.52) and pA2 (7.6) value was screened for its neuro-pharmacological potential in chronic rodent models of depression and anxiety named traumatic brain injury (TBI). |
URI: | https://www.degruyter.com/document/doi/10.1515/jbcpp-2016-0057/html http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13226 |
Appears in Collections: | Department of Pharmacy |
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