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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mahesh, R. | - |
dc.date.accessioned | 2023-11-23T06:35:42Z | - |
dc.date.available | 2023-11-23T06:35:42Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.uri | https://www.sysrevpharm.org/abstract/role-of-serotonin-type1ab-hydroxytryptamine-receptors-in-depression-revisited-64927.html | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13233 | - |
dc.description.abstract | Depression is among the common psychiatric disorders, therefore the common pathways and pathogenesis associated with depression is required to be studied. In few years, role of 5-hydroxytryptamine-1A/B (5-HT1A/B) receptors in depressive disorders have been revealed. Both preclinical and clinical studies reported that the potential agonist and antagonist at 5-HT1A/B receptors have significant modulatory effects in depression. However, the collective details regarding the involvement of 5-HT1A/B receptors and the molecular pathways associated in depression is lacking. Thus, the present review evidence the link between 5-HT1A/B receptors in the brain and depression, the possible pathways involved and their alterations in depression. Further, it reviews the preclinical evidences of 5-HT1A/B receptor modulators as antidepressant agents and their effectiveness. The current review also details the clinical relevance of 5-HT1A/B receptors etiopathogenesis of major depression in humans. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Systematic Reviews in Pharmacy | en_US |
dc.subject | Pharmacy | en_US |
dc.subject | 5-hydroxytryptophan | en_US |
dc.subject | Antidepressant | en_US |
dc.subject | Depression | en_US |
dc.subject | Molecular signaling | en_US |
dc.title | Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Pharmacy |
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