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Title: | Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited |
Authors: | Mahesh, R. |
Keywords: | Pharmacy 5-hydroxytryptophan Antidepressant Depression Molecular signaling |
Issue Date: | Apr-2014 |
Publisher: | Systematic Reviews in Pharmacy |
Abstract: | Depression is among the common psychiatric disorders, therefore the common pathways and pathogenesis associated with depression is required to be studied. In few years, role of 5-hydroxytryptamine-1A/B (5-HT1A/B) receptors in depressive disorders have been revealed. Both preclinical and clinical studies reported that the potential agonist and antagonist at 5-HT1A/B receptors have significant modulatory effects in depression. However, the collective details regarding the involvement of 5-HT1A/B receptors and the molecular pathways associated in depression is lacking. Thus, the present review evidence the link between 5-HT1A/B receptors in the brain and depression, the possible pathways involved and their alterations in depression. Further, it reviews the preclinical evidences of 5-HT1A/B receptor modulators as antidepressant agents and their effectiveness. The current review also details the clinical relevance of 5-HT1A/B receptors etiopathogenesis of major depression in humans. |
URI: | https://www.sysrevpharm.org/abstract/role-of-serotonin-type1ab-hydroxytryptamine-receptors-in-depression-revisited-64927.html http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13233 |
Appears in Collections: | Department of Pharmacy |
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