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DC Field | Value | Language |
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dc.contributor.author | Mahesh, R. | - |
dc.date.accessioned | 2023-11-24T07:09:42Z | - |
dc.date.available | 2023-11-24T07:09:42Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://www.thepharmajournal.com/archives/2013/vol2issue6/PartA/4.1.pdf | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13254 | - |
dc.description.abstract | The serotonergic system of brain is well understood to play a crucial role in emotional processing in human and animals. 5-HT3 receptor, the ion channel type of receptor is involved in mood, anxiety, depression, learning and memory. Objective of the present work was to investigate the anxiolytic potential of a novel 5-HT3 receptor antagonist (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a) in mice. Different behavioral test paradigms for anxiety like elevated plus maze, open field test, light-dark model and hole board test were used for assessing the effect. Diazepam 2 mg/kg i.p. served as a reference standard. From the results it was found that 4a dose dependently at 2 and 4 mg/kg i.p. attenuated the behavioral alterations in the anxiety models in mice. The exact mechanism of 5- HT3 receptor antagonist for anxiolytic potential is still ill understood. Our further studies will deal with mechanisms at molecular levels for anxiolytic potential of 4a | en_US |
dc.language.iso | en | en_US |
dc.publisher | The Pharma Innovation | en_US |
dc.subject | Pharmacy | en_US |
dc.subject | 5-HT3 Receptor | en_US |
dc.subject | Anxiety | en_US |
dc.subject | Elevated plus maze (EPM) | en_US |
dc.subject | Open field test (OFT) | en_US |
dc.title | Anxiolytic Effect of a Novel 5-HT3 Receptor Antagonist (4-Phenylpiperazin-1-yl)(Quinoxalin-2-yl) Methanone (4a) in a Battery of Behavioral Models for Anxiety in Mice | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Pharmacy |
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