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Title: | Dynamin Functions and Ligands: Classical Mechanisms Behind |
Authors: | Mahesh, R. |
Keywords: | Pharmacy GTPase Mitochondrial fusion/fission Alzheimer’s disease Parkinson’s disease |
Issue Date: | Feb-2017 |
Publisher: | American Society for Pharmacology and Experimental Therapeutics |
Abstract: | Dynamin is a GTPase that plays a vital role in clathrin-dependent endocytosis and other vesicular trafficking processes by acting as a pair of molecular scissors for newly formed vesicles originating from the plasma membrane. Dynamins and related proteins are important components for the cleavage of clathrin-coated vesicles, phagosomes, and mitochondria. These proteins help in organelle division, viral resistance, and mitochondrial fusion/fission. Dysfunction and mutations in dynamin have been implicated in the pathophysiology of various disorders, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Charcot-Marie-Tooth disease, heart failure, schizophrenia, epilepsy, cancer, dominant optic atrophy, osteoporosis, and Down’s syndrome. This review is an attempt to illustrate the dynamin-related mechanisms involved in the above-mentioned disorders and to help medicinal chemists to design novel dynamin ligands, which could be useful in the treatment of dynamin-related disorders. |
URI: | https://molpharm.aspetjournals.org/content/91/2/123.abstract http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13268 |
Appears in Collections: | Department of Pharmacy |
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