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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mahesh, R. | - |
dc.date.accessioned | 2023-11-24T10:31:35Z | - |
dc.date.available | 2023-11-24T10:31:35Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.uri | https://molpharm.aspetjournals.org/content/91/2/123.abstract | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13268 | - |
dc.description.abstract | Dynamin is a GTPase that plays a vital role in clathrin-dependent endocytosis and other vesicular trafficking processes by acting as a pair of molecular scissors for newly formed vesicles originating from the plasma membrane. Dynamins and related proteins are important components for the cleavage of clathrin-coated vesicles, phagosomes, and mitochondria. These proteins help in organelle division, viral resistance, and mitochondrial fusion/fission. Dysfunction and mutations in dynamin have been implicated in the pathophysiology of various disorders, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Charcot-Marie-Tooth disease, heart failure, schizophrenia, epilepsy, cancer, dominant optic atrophy, osteoporosis, and Down’s syndrome. This review is an attempt to illustrate the dynamin-related mechanisms involved in the above-mentioned disorders and to help medicinal chemists to design novel dynamin ligands, which could be useful in the treatment of dynamin-related disorders. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Society for Pharmacology and Experimental Therapeutics | en_US |
dc.subject | Pharmacy | en_US |
dc.subject | GTPase | en_US |
dc.subject | Mitochondrial fusion/fission | en_US |
dc.subject | Alzheimer’s disease | en_US |
dc.subject | Parkinson’s disease | en_US |
dc.title | Dynamin Functions and Ligands: Classical Mechanisms Behind | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Pharmacy |
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