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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Taliyan, Rajeev | - |
dc.date.accessioned | 2023-12-12T10:34:08Z | - |
dc.date.available | 2023-12-12T10:34:08Z | - |
dc.date.issued | 2014-12 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s00210-014-1081-2 | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13372 | - |
dc.description.abstract | Recent studies suggest the importance of combined treatment of glycogen synthase kinase-3β (GSK-3β) and histone deacetylase (HDAC) inhibition in various in vitro and in vivo models of neurological diseases. Lithium chloride (LiCl) and valproate (VPA), two well-known mood stabilizers, have been reported to act through GSK-3β and HDAC inhibition, respectively. The present study was designed to investigate the potential of low-dose combination of LiCl and VPA in intracerebroventricular streptozotocin (ICV-STZ)-induced cognitive deficits in rats. STZ was injected twice (3 mg/kg ICV) on alternate days (day 1 and day 3) in rats. The ICV-STZ-treated rats received LiCl (60 mg/kg, i.p.), VPA (200 mg/kg, i.p.), and combination of both LiCl (60 mg/kg, i.p.) and VPA (200 mg/kg, i.p.) drugs for a period of 3 weeks. The ICV-STZ administration results in significant memory impairment, elevated oxidative-nitrosative stress, and reduced brain-derived neurotrophic factor (BDNF) levels. Using a battery of behavioral and biochemical tests, we observed that co-treatment of both drugs showed synergistic effect in improving the spatial learning and memory impairment as well as significantly attenuated the oxidative stress markers in STZ-treated rats as compared to either drug alone. Moreover, the combination of both drugs reversed the hyperinsulinemic brain condition and improved the BDNF levels in STZ-treated rats. Based upon these results, it could be suggested that a low-dose combination of LiCl and VPA produces synergistic and more consistent neuroprotective effects in ICV-STZ-induced cognitive deficits in rats | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.subject | Pharmacy | en_US |
dc.subject | Histone deacetylase (HDAC) | en_US |
dc.subject | Lithium chloride (LiCl) | en_US |
dc.title | Synergistic effects of GSK-3β and HDAC inhibitors in intracerebroventricular streptozotocin-induced cognitive deficits in rats | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Pharmacy |
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