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http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13377| Title: | Neuroprotective effect of hydroxy safflor yellow A against cerebral ischemia-reperfusion injury in rats: putative role of mPTP |
| Authors: | Taliyan, Rajeev |
| Keywords: | Pharmacy Carboxyatractyloside Cerebral ischemic-reperfusion injury Hydroxy safflor yellow A (HSYA) Mitochondrial permeability transition pore (mPTP) |
| Issue Date: | Aug-2015 |
| Publisher: | De Gruyter |
| Abstract: | Hydroxy safflor yellow A (HSYA) has been translated clinically for cardiovascular diseases. HSYA is also greatly acknowledged for its protective effects against cerebral ischemic-reperfusion (I/R) injury. Although the precise mechanism of cerebral I/R injury is not fully understood, oxygen-derived free radicals and mitochondrial permeability transition pore (mPTP) opening during I/R injury are widely recognized as an important contributor to neuronal injury. Thus, we speculated that the neuroprotective effects of HSYA against cerebral I/R injury may be associated with mPTP modulation. |
| URI: | https://www.degruyter.com/document/doi/10.1515/jbcpp-2015-0021/html http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13377 |
| Appears in Collections: | Department of Pharmacy |
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