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Title: | Fibroblast Growth Factor 21 and Autophagy Modulation Ameliorates Amyloid β-Induced Alzheimer Disease Pathology in Rats |
Authors: | Taliyan, Rajeev |
Keywords: | Pharmacy Alzheimer's disease (AD) Neurodegenerative condition |
Issue Date: | Dec-2021 |
Publisher: | Wiley |
Abstract: | Alzheimer's disease (AD) is a multifactorial neurodegenerative condition and the most common cause of its initiation is accumulation of oligomeric amyloid beta1-42 (Aβ1-42). In recent past, several studies have shown autophagy deficits in AD may resulted accumulation of misfolded protein, Aβ1-42 and phosphorylated tau (ptau). Fibroblast growth factor 21 (FGF21), a metabolic hormone, has shown strong neuroprotective efficacy via increasing autophagic flux in AD. Therefore, this study was designed to investigate the synergistic neuroprotective efficacy of lentiviral FGF21 gene (LV-FGF21) delivery and rapamycin-autophagy modulator in Aβ1-42 induced AD in rats. |
URI: | https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.058695 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13413 |
Appears in Collections: | Department of Pharmacy |
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