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Title: | [P2–130]: AR-A014418, A GSK-3β INHIBITOR, ATTENUATES ALZHEIMER'S- LIKE PATHOLOGY IN HIGH FAT DIET-INDUCED COGNITIVE DEFICIT IN MICE |
Authors: | Taliyan, Rajeev |
Keywords: | Pharmacy Alzheimer's disease (AD) Glycogen synthase kinase-3β High Fat Diet (HFD) |
Issue Date: | Jul-2017 |
Publisher: | Wiley |
Abstract: | Alzheimer's disease (AD) is characterized by the progressive deposition of fibrillar amyloid-β (Aβ) in the form of extracellular plaques and hyperphosphorylated tau as intraneuronal neuro fibrillary tangles (NFTs). Studies have reported that increased Glycogen synthase kinase-3β (GSK-3β) activity has been associated with hyper phosphorylation of tau. However, the molecular mechanisms of association still remain elusive. Thus, the present study was designed to explore the potential of GSK-3β inhibitor, AR-A014418 in high fat diet (HFD) induced cognitive impairment and AD like pathology. |
URI: | https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1016/j.jalz.2017.06.780 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13421 |
Appears in Collections: | Department of Pharmacy |
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