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Title: | High fat diet feeding exacerbates the toxic effects of 6-hydroxydopamine in rats: Possible involvement of histone acetylation |
Authors: | Taliyan, Rajeev |
Keywords: | Pharmacy Histone acetylation Parkinson's disease (PD) |
Issue Date: | Jan-2016 |
Publisher: | Elsevier |
Abstract: | Clinical evidence has shown a correlation between Parkinson's disease (PD) and type 2 diabetes, as abnormal glucose tolerance has been reported in >50% of PD patients. Recently, insulin resistance was found to be present in 62% of PD patients with dementia, of whom 30% were glucose intolerant [1]. However, the underlying pathways are still elusive. Therefore, the present study was designed to explore the effect of insulin resistance on striatal dopaminergic neurons in an animal model of PD. |
URI: | https://www.prd-journal.com/article/S1353-8020(15)00890-1/fulltext http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13422 |
Appears in Collections: | Department of Pharmacy |
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