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Title: | Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats |
Authors: | Gaikwad, Anil Bhanudas |
Keywords: | Pharmacy Cisplatin Nephrotoxicity Poly(ADP-ribose) polymerase Histone H4 P-p38 and Tannic acid |
Issue Date: | May-2007 |
Publisher: | Elsevier |
Abstract: | Cisplatin is a widely used antineoplastic drug. Major drawback of cisplatin therapy is its nephrotoxicity. The objective of this study was to check the effect of tannic acid on cisplatin induced nephrotoxicity. Post-treatment of tannic acid prevents cisplatin (5 mg/kg) induced nephrotoxicity and decreases poly(ADP-ribose) polymerase cleavage, phosphorylation of p38 and hypoacetylation of histone H4. In contrast, co-treatment of tannic acid potentiates the nephrotoxicity. Comparative nephrotoxicity studies show that co-treatment of tannic acid with reduced dose of cisplatin (1.5 mg/kg) developed almost similar nephrotoxicity. MALDI protein profiling of plasma samples provides indirect evidence that tannic acid co-treatment increases bioavailability of cisplatin. |
URI: | https://www.sciencedirect.com/science/article/pii/S0014579307004231 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13443 |
Appears in Collections: | Department of Pharmacy |
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