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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13443
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dc.contributor.authorGaikwad, Anil Bhanudas-
dc.date.accessioned2023-12-19T04:23:58Z-
dc.date.available2023-12-19T04:23:58Z-
dc.date.issued2007-05-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0014579307004231-
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13443-
dc.description.abstractCisplatin is a widely used antineoplastic drug. Major drawback of cisplatin therapy is its nephrotoxicity. The objective of this study was to check the effect of tannic acid on cisplatin induced nephrotoxicity. Post-treatment of tannic acid prevents cisplatin (5 mg/kg) induced nephrotoxicity and decreases poly(ADP-ribose) polymerase cleavage, phosphorylation of p38 and hypoacetylation of histone H4. In contrast, co-treatment of tannic acid potentiates the nephrotoxicity. Comparative nephrotoxicity studies show that co-treatment of tannic acid with reduced dose of cisplatin (1.5 mg/kg) developed almost similar nephrotoxicity. MALDI protein profiling of plasma samples provides indirect evidence that tannic acid co-treatment increases bioavailability of cisplatin.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectPharmacyen_US
dc.subjectCisplatinen_US
dc.subjectNephrotoxicityen_US
dc.subjectPoly(ADP-ribose) polymeraseen_US
dc.subjectHistone H4en_US
dc.subjectP-p38 and Tannic aciden_US
dc.titleDifferential effects of tannic acid on cisplatin induced nephrotoxicity in ratsen_US
dc.typeArticleen_US
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