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http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13452| Title: | Telmisartan and thiorphan combination treatment attenuates fibrosis and apoptosis in preventing diabetic cardiomyopathy |
| Authors: | Gaikwad, Anil Bhanudas |
| Keywords: | Pharmacy LCZ696, Cardiomyopathy Diabetic nephropathy |
| Issue Date: | Sep-2018 |
| Publisher: | Oxford |
| Abstract: | LCZ696, a first-generation dual angiotensin receptor-neprilysin inhibitor (ARNi), is effective in treating heart failure patients. However, the role of ARNis in treating diabetic cardiomyopathy is poorly understood. This study evaluates the efficacy of a novel combination of telmisartan [angiotensin receptor blocker (ARB)] and thiorphan [neprilysin inhibitor (NEPi)] in ameliorating diabetic cardiomyopathy while, at the same time, exploring the relevant underlying molecular mechanism(s). |
| URI: | https://academic.oup.com/cardiovascres/article/115/2/373/5090455?login=true http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13452 |
| Appears in Collections: | Department of Pharmacy |
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