Phloretin as an add-on therapy to losartan attenuates diabetes-induced AKI in rats: A potential therapeutic approach targeting TLR4-induced inflammation

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Title:	Phloretin as an add-on therapy to losartan attenuates diabetes-induced AKI in rats: A potential therapeutic approach targeting TLR4-induced inflammation
Authors:	Gaikwad, Anil Bhanudas
Keywords:	Pharmacy Inflammation Phloretin Toll-like receptor-4 (TLR4) Diabetes Acute Kidney Injury (AKI)
Issue Date:	Nov-2023
Publisher:	Elsevier
Abstract:	Targeting Toll-like receptor 4 (TLR4) and Angiotensin II type 1 receptor (AT1R) could provide renoprotection during acute kidney injury (AKI) mainly by regulating inflammation, oxidative stress, mitochondrial dysfunction, and apoptosis. Phloretin (TLR4 inhibitor) as an add-on therapy to losartan (AT1R inhibitor) could provide more therapeutic benefits against AKI under diabetic condition. We aimed to study the effect of phloretin as an add-on therapy to losartan against AKI under diabetic condition.
URI:	https://www.sciencedirect.com/science/article/pii/S0024320523007300 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13528
Appears in Collections:	Department of Pharmacy

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