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Title: | P0527 Hyperglycemia-associated Acute Kidney Injury Increases the Susceptibility Towards Neurological Dysfunction: Role of Angiotensin Ii Type 2 Receptor and Angiotensin-converting Enzyme 2 |
Authors: | Gaikwad, Anil Bhanudas |
Keywords: | Pharmacy Cytokine storm Ischemic renal injury (IRI) Enzyme inhibition |
Issue Date: | Jun-2020 |
Publisher: | OUP |
Abstract: | In clinical settings, diabetics remain on higher risk of ischemic renal injury (IRI) than nondiabetic patients. In addition, IRI predisposes distant organs to dysfunction such as neurological impairments via activation of the pressor arm of renin-angiotensin system (RAS). In contrast, the role of depressor arm of RAS on IRI-associated neurological sequalae remains elusive. Hence, this study explored the role of angiotensin II type 2 receptor (AT2R) and angiotensin-converting enzyme 2 (ACE2) in IRI-associated neurological dysfunctions under nondiabetic (ND) and diabetes mellitus (DM) condition. |
URI: | https://academic.oup.com/ndt/article/35/Supplement_3/gfaa142.P0527/5852684 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13532 |
Appears in Collections: | Department of Pharmacy |
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