Please use this identifier to cite or link to this item:
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13537
Title: | Modulating TNF-α signaling with natural products |
Authors: | Paul, Atish Tulshiram |
Keywords: | Pharmacy Necrosis factor-α (TNF-α) |
Issue Date: | Aug-2006 |
Publisher: | Elsevier |
Abstract: | Natural products have been, and continue to be, a major source of pharmacologically active substances from which drugs can be developed. Currently, tumor necrosis factor-α (TNF-α) inhibitors from natural origins are being advanced for the treatment of inflammatory disorders. Elevated TNF-α synthesis has been associated with the development of diabetes, septic shock, tumorigenesis, rheumatoid arthritis, psoriatic arthritis and inflammatory bowel disease. Currently, only protein-based drugs are available for the clinical inhibition of TNF-α activity. Small-molecule drugs that can regulate TNF-α levels or activity might provide a cost-effective alternative to protein-based therapeutics. This review briefly highlights the physiological and pathological roles of TNF-α, and covers those natural compounds capable of interfering with TNF-α activity. |
URI: | https://www.sciencedirect.com/science/article/pii/S135964460600184X http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13537 |
Appears in Collections: | Department of Pharmacy |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.