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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Paul, Atish Tulshiram | - |
dc.date.accessioned | 2023-12-27T09:00:38Z | - |
dc.date.available | 2023-12-27T09:00:38Z | - |
dc.date.issued | 2006-08 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S135964460600184X | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13537 | - |
dc.description.abstract | Natural products have been, and continue to be, a major source of pharmacologically active substances from which drugs can be developed. Currently, tumor necrosis factor-α (TNF-α) inhibitors from natural origins are being advanced for the treatment of inflammatory disorders. Elevated TNF-α synthesis has been associated with the development of diabetes, septic shock, tumorigenesis, rheumatoid arthritis, psoriatic arthritis and inflammatory bowel disease. Currently, only protein-based drugs are available for the clinical inhibition of TNF-α activity. Small-molecule drugs that can regulate TNF-α levels or activity might provide a cost-effective alternative to protein-based therapeutics. This review briefly highlights the physiological and pathological roles of TNF-α, and covers those natural compounds capable of interfering with TNF-α activity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Pharmacy | en_US |
dc.subject | Necrosis factor-α (TNF-α) | en_US |
dc.title | Modulating TNF-α signaling with natural products | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Pharmacy |
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