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Title: | Evaluation of Proinflammatory Cytokine Pathway Inhibitors for p38 MAPK Inhibitory Potential |
Authors: | Paul, Atish Tulshiram |
Keywords: | Pharmacy Inhibitors Ligands Molecular interactions Peptides and proteins |
Issue Date: | Nov-2007 |
Publisher: | ACS |
Abstract: | The target for the anti-inflammatory natural products like amentoflavone (2), which act by interfering with the proinflammatory cytokine pathway (e.g., TNF-α, IL-1β, and NO synthase), is not yet well-defined. Data obtained from docking, electronic, and surface analyses shed some light on steric and electronic complementarity of these molecules to p38 MAPK, thereby suggesting a possible mechanism by which they might reduce the production of proinflammatory cytokines. |
URI: | https://pubs.acs.org/doi/full/10.1021/jm0706923 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13551 |
Appears in Collections: | Department of Pharmacy |
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