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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13586
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dc.contributor.authorPaul, Atish Tulshiram-
dc.date.accessioned2024-01-02T04:25:45Z-
dc.date.available2024-01-02T04:25:45Z-
dc.date.issued2024-01-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1359644623003719-
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13586-
dc.description.abstractObesity is a disease of epidemic proportions, with a worrisome upward trend. The high consumption of lipids, a major energy source, leads to obesity because of their high calorific value. Pancreatic lipase (PTL), produced by pancreatic acinar cells, hydrolyzes 50–70% of triacylglycerol (TAG) from food. PTL-related protein 1 (PLRP1) and 2 (PLRP2) are also produced by these cells. In vertebrates, PLRP1 has relatively less lipolytic activity, whereas PLRP2 has an essential role in lipid digestion, especially in infants. In this review, we summarize the structure and function of PTL, PLRP1, and PLRP2, and the metabolic fate of PTL inhibitors. We also discuss the current status of clinical trials on orlistat and its combinations for obesity treatment.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectPharmacyen_US
dc.subjectPancreatic lipaseen_US
dc.subjectObesityen_US
dc.subjectCatalytic triaden_US
dc.subjectOrlistaten_US
dc.subjectCetilistaten_US
dc.titlePancreatic lipase and its related proteins: where are we now?en_US
dc.typeArticleen_US
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