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http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13641
Title: | miRNA profiling in pancreatic cancer and restoration of chemosensitivity |
Authors: | Chitkara, Deepak |
Keywords: | Pharmacy Pancreatic cancer Chemoresistance miRNAs Gemcitabine Cancer stem cells |
Issue Date: | Jul-2013 |
Publisher: | Elsevier |
Abstract: | Pancreatic cancers relapse due to small but distinct population of cancer stem cells (CSCs) which are in turn regulated by miRNAs. The present study identifies a series of miRNAs which were either upregulated (e.g. miR-146) or downregulated (e.g. miRNA-205, miRNA-7) in gemcitabine resistant MIA PaCa-2 cancer cells and clinical metastatic pancreatic cancer tissues. Gemcitabine resistant MIA PaCa-2 cells possessed distinct ALDH-positive CSC fraction expressing stem cell markers OCT3/4 and CD44 and chemoresistance marker class III β-tubulin (TUBB3) which decreases on transfection with miR-205 resulting in the restoration of chemosensitivity to gemcitabine. |
URI: | https://www.sciencedirect.com/science/article/pii/S0304383512005964 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13641 |
Appears in Collections: | Department of Pharmacy |
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