Docetaxel and alpha-lipoic acid co-loaded nanoparticles for cancer therapy

Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/13662

Title:	Docetaxel and alpha-lipoic acid co-loaded nanoparticles for cancer therapy
Authors:	Chitkara, Deepak Mittal, Anupama
Keywords:	Pharmacy Breast cancer Solid lipid nanoparticles (SLNs) Cellular uptake
Issue Date:	Apr-2019
Publisher:	Future Science Group
Abstract:	The current study aims to co-deliver docetaxel (DTX) and alpha-lipoic acid (ALA) using solid lipid nanoparticles (SLNs) as a carrier for the treatment of breast cancer. Methods: Computational analysis was used to screen different solid lipids as carriers, following which SLNs were prepared and characterized. Furthermore, antioxidant activity assays and cell culture studies were performed. Results:In vitro assessment in 4T1 (murine mammary carcinoma) and MCF-7 (human breast adenocarcinoma) cells revealed enhanced efficacy of the co-loaded SLNs as compared with free drugs and single drug-loaded SLNs. Increased apoptosis following treatment with DTX-ALA co-loaded SLN was also observed
URI:	https://www.future-science.com/doi/abs/10.4155/tde-2018-0074 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13662
Appears in Collections:	Department of Pharmacy

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