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Title: | Structural modifications in polymeric micelles to impart multifunctionality for improved drug delivery |
Authors: | Mittal, Anupama Chitkara, Deepak |
Keywords: | Pharmacy Cross-linked Stimuli-responsive Site-specific Polymeric micelles |
Issue Date: | Jan-2016 |
Publisher: | Future Science Group |
Abstract: | Polymeric micelles are macromolecular nanoconstructs which are formed by self-assembly of synthetic amphiphilic block copolymers. These copolymers could be chemically modified to expand their functionality and hence obtain a multifunctional micelle which could serve several functions simultaneously, for example, long circulation time along with active targeting, smart polymeric micelles providing on-demand drug release for example, pH responsive micelles, redox- and light-sensitive micelles, charge-conversion micelles and core/shell cross-linked micelles. Additionally, micelles could be tailored to carry a contrast agent or siRNA/miRNA along with the drug for greater clinical benefit. The focus of the current commentary would be to highlight such chemical modifications which impart multifunctionality to a single carrier and discuss challenges involved in clinical translation of these multifunctional micelles. |
URI: | https://www.future-science.com/doi/abs/10.4155/tde.15.90 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13674 |
Appears in Collections: | Department of Pharmacy |
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