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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/13696
Title: (Re)Formulating rotigotine: a potential molecule with unmet needs
Authors: Pandey, Murali Monohar
Chitkara, Deepak
Keywords: Pharmacy
Rotigotine (RTG)
Parkinson's disease
Alzheimer's disease
Traumatic brain injury (TBI)
Nanoformulations
Issue Date: Jan-2023
Publisher: Future Science Group
Abstract: Rotigotine (RTG), a non-ergoline D3/D2/D1 dopamine receptor agonist, is indicated for Parkinson’s disease (PD) and restless leg syndrome (RLS)[1]. It also has an affinity toward serotonin (5-HT1A, 5-HT2B, and 5-HT7) and α2B-adrenergic receptors [2]. At present, RTG is commercially available as an extended-release transdermal patch since it shows poor oral bioavailability because of its extensive first-pass metabolism [3]. Although successfully marketed, RTG potential has not been fully utilized owing to the challenges and drawbacks associated with its delivery. For instance, the absolute bioavailability from the transdermal patch is reported to be only 37%. The absolute bioavailability of transdermal patches varies depending on its site of application [3]. Moreover, RTG forms crystals in the transdermal patch upon storage and shows variations in drug release and bioavailability as well
URI: https://www.future-science.com/doi/abs/10.4155/tde-2022-0046?journalCode=tde
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13696
Appears in Collections:Department of Pharmacy

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