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http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/13838| Title: | Development and Validation of a Simple High-Performance Liquid Chromatography Method for Estimation of Felodipine in Rabbit Plasma: Application to Pharmacokinetic Study |
| Authors: | Pandey, Murali Monohar |
| Keywords: | Pharmacy Felodipine Fluorescence detector High-performance liquid chromatography Rabbit plasma Pharmacokinetic study Oral tablet |
| Issue Date: | 2017 |
| Publisher: | Bentham Science |
| Abstract: | A new, simple, specific and sensitive reverse-phase liquid chromatographic method was developed and validated for the estimation of felodipine (FDP) in rabbit plasma using fluorescence detector. Materials and Methods: Plasma standard were prepared using a simple and one-step protein precipitation method and 50 μ l of the standard solutions were injected into the column. The method was found to be linear in the concentration range of 10–1000 ng/ml. The developed bioanalytical method was validated as per standard guidelines. Validation study results demonstrated accuracy, precision, sensitivity and selectivity of the proposed method. |
| URI: | https://www.eurekaselect.com/article/77973 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13838 |
| Appears in Collections: | Department of Pharmacy |
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