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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/13840
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dc.contributor.authorPandey, Murali Monohar-
dc.date.accessioned2024-01-13T06:52:55Z-
dc.date.available2024-01-13T06:52:55Z-
dc.date.issued2014-06-
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/10717544.2014.917388-
dc.identifier.urihttps://dspace.bits-pilani.ac.in/xmlui/handle/123456789/13840-
dc.description.abstractIn the present study controlled release effervescent buccal discs of buspirone hydrochloride (BS) were designed using HPMC as rate controlling and bioadhesive polymer by direct compression method. Sodium bicarbonate and citric acid were used in varying amounts as effervescence forming agents. Carbon dioxide evolved due to reaction of sodium bicarbonate and citric acid was explored for its potential as buccal permeation enhancer. The designed buccal discs were evaluated for physical characteristics and in vitro drug release studies. Bioadhesive behavior of designed buccal discs was assessed using texture analyzer. In vivo animal studies were performed in rabbits to study bioavailability of BS in the designed buccal discs and to establish permeation enhancement ability of carbon dioxide. It was observed that effervescent buccal discs have faster drug release compared to non-effervescent buccal discs in vitro and effervescent buccal discs demonstrated significant increase in bioavailability of drug when compared to non-effervescent formulation. Hence, effervescent buccal discs can be used as an alternative to improve the drug permeation resulting in better bioavailability. However, the amount of acid and base used for generation of carbon dioxide should be selected with care as this may damage the integrity of bioadhesive dosage form.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectPharmacyen_US
dc.subjectPharmacokineticsen_US
dc.subjectEffervescenten_US
dc.subjectDrug Deliveryen_US
dc.subjectBuspirone hydrochlorideen_US
dc.subjectBuccal discsen_US
dc.titleControlled release effervescent buccal discs of buspirone hydrochloride: in vitro and in vivo evaluation studiesen_US
dc.typeArticleen_US
Appears in Collections:Department of Pharmacy

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