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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/13843
Title: Interaction of calcium sulfate with xanthan gum: Effect on in vitro bioadhesion and drug release behavior from xanthan gum based buccal discs of buspirone
Authors: Pandey, Murali Monohar
Keywords: Pharmacy
Xanthan gum
Calcium sulfate
Buccal discs
Bioadhesion
Drug Delivery
Viscosity
Issue Date: Nov-2013
Publisher: Elsevier
Abstract: Bioadhesive polymers in buccal drug delivery systems play an important role in delivery of therapeutic drug molecules for local and systemic action. Xanthan gum, a GRAS listed natural polymer was used to design buccal discs of buspirone hydrochloride by direct compression method. Effect of calcium sulfate on bioadhesive and drug release behavior of xanthan gum buccal discs was studied. Varying amount of calcium sulfate (0%, 5%, 10%, 20%, 30%, 40% and 50%, w/w) in combination with xanthan gum was used to prepare buccal bioadhesive discs. Increase in calcium sulfate concentration resulted in faster drug release and decreased the bioadhesive strength of the designed discs. Further, in rheological evaluation it was observed that viscosity of xanthan gum gel reduces with increasing concentration of calcium sulfate. Compatibility of drug with various excipients was assessed using DSC and FTIR techniques.
URI: https://www.sciencedirect.com/science/article/pii/S0927776513004311
https://dspace.bits-pilani.ac.in/xmlui/handle/123456789/13843
Appears in Collections:Department of Pharmacy

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