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http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13851| Title: | New PPARγ ligands based on barbituric acid: Virtual screening, synthesis and receptor binding studies |
| Authors: | Sundriyal, Sandeep |
| Keywords: | Pharmacy PPARγ Virtual screening Docking Diabetes Barbituric acid Rosiglitazone |
| Issue Date: | Sep-2008 |
| Publisher: | Elsevier |
| Abstract: | A new series of PPARγ ligands based on barbituric acid (BA) has been designed employing virtual screening and molecular docking approach. To validate the computational approach, designed molecules were synthesized and evaluated in in vitro radioligand binding studies. Out of the total 14 molecules, 6 were found to bind to the murine PPARγ with IC50 ranging from 0.1 to 2.5 μM as compared to reference standard, pioglitazone (IC50 = 0.7 μM). |
| URI: | https://www.sciencedirect.com/science/article/pii/S0960894X08009505 http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13851 |
| Appears in Collections: | Department of Pharmacy |
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