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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/13851
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dc.contributor.authorSundriyal, Sandeep-
dc.date.accessioned2024-01-17T04:42:16Z-
dc.date.available2024-01-17T04:42:16Z-
dc.date.issued2008-09-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0960894X08009505-
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13851-
dc.description.abstractA new series of PPARγ ligands based on barbituric acid (BA) has been designed employing virtual screening and molecular docking approach. To validate the computational approach, designed molecules were synthesized and evaluated in in vitro radioligand binding studies. Out of the total 14 molecules, 6 were found to bind to the murine PPARγ with IC50 ranging from 0.1 to 2.5 μM as compared to reference standard, pioglitazone (IC50 = 0.7 μM).en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectPharmacyen_US
dc.subjectPPARγen_US
dc.subjectVirtual screeningen_US
dc.subjectDockingen_US
dc.subjectDiabetesen_US
dc.subjectBarbituric aciden_US
dc.subjectRosiglitazoneen_US
dc.titleNew PPARγ ligands based on barbituric acid: Virtual screening, synthesis and receptor binding studiesen_US
dc.typeArticleen_US
Appears in Collections:Department of Pharmacy

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