2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases

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DC Field	Value	Language
dc.contributor.author	Sundriyal, Sandeep	-
dc.date.accessioned	2024-01-17T04:44:28Z	-
dc.date.available	2024-01-17T04:44:28Z	-
dc.date.issued	2022-10	-
dc.identifier.uri	https://www.sciencedirect.com/science/article/pii/S0960894X12010013	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13852	-
dc.description.abstract	Bacterial resistance to β-lactam antibiotics caused by class B metallo-β-lactamases (MBL), especially for certain hospital-acquired, Gram-negative pathogens, poses a significant threat to public health. We report several 2-substituted 4,5-dihydrothiazole-4-carboxylic acids to be novel MBL inhibitors. Structure activity relationship (SAR) and molecular modeling studies were performed and implications for further inhibitor design are discussed.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsevier	en_US
dc.subject	Pharmacy	en_US
dc.subject	Metallo-β-lactamase	en_US
dc.subject	Inhibitor	en_US
dc.subject	Rational design	en_US
dc.subject	Molecular modeling	en_US
dc.title	2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Pharmacy

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