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Title: | New Antimicrobial Hexapeptides: Synthesis, Antimicrobial Activities, Cytotoxicity, and Mechanistic Studies |
Authors: | Sundriyal, Sandeep |
Keywords: | Pharmacy Cytotoxicity Antimicrobial Activities Synthesis Antimicrobial Hexapeptides |
Issue Date: | Dec-2009 |
Publisher: | Wiley |
Abstract: | The lead optimization of an antimicrobial hexapeptide Orn-D-Trp-D-Phe-Ile-D-Phe-His(1-Bzl)-NH2 depending on the hydrophobic or positive-charge character of amino acids at various positions along its sequence was performed, followed by biological evaluation and mechanistic studies. This led to the identification of a new class of antimicrobial hexapeptides that interact preferentially with the negatively charged phospholipids of a model bacterial membrane. |
URI: | https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.200900330 http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13853 |
Appears in Collections: | Department of Pharmacy |
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