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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/13853
Title: New Antimicrobial Hexapeptides: Synthesis, Antimicrobial Activities, Cytotoxicity, and Mechanistic Studies
Authors: Sundriyal, Sandeep
Keywords: Pharmacy
Cytotoxicity
Antimicrobial Activities
Synthesis
Antimicrobial Hexapeptides
Issue Date: Dec-2009
Publisher: Wiley
Abstract: The lead optimization of an antimicrobial hexapeptide Orn-D-Trp-D-Phe-Ile-D-Phe-His(1-Bzl)-NH2 depending on the hydrophobic or positive-charge character of amino acids at various positions along its sequence was performed, followed by biological evaluation and mechanistic studies. This led to the identification of a new class of antimicrobial hexapeptides that interact preferentially with the negatively charged phospholipids of a model bacterial membrane.
URI: https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.200900330
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13853
Appears in Collections:Department of Pharmacy

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