New Antimicrobial Hexapeptides: Synthesis, Antimicrobial Activities, Cytotoxicity, and Mechanistic Studies

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DC Field	Value	Language
dc.contributor.author	Sundriyal, Sandeep	-
dc.date.accessioned	2024-01-17T04:55:07Z	-
dc.date.available	2024-01-17T04:55:07Z	-
dc.date.issued	2009-12	-
dc.identifier.uri	https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.200900330	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13853	-
dc.description.abstract	The lead optimization of an antimicrobial hexapeptide Orn-D-Trp-D-Phe-Ile-D-Phe-His(1-Bzl)-NH2 depending on the hydrophobic or positive-charge character of amino acids at various positions along its sequence was performed, followed by biological evaluation and mechanistic studies. This led to the identification of a new class of antimicrobial hexapeptides that interact preferentially with the negatively charged phospholipids of a model bacterial membrane.	en_US
dc.language.iso	en	en_US
dc.publisher	Wiley	en_US
dc.subject	Pharmacy	en_US
dc.subject	Cytotoxicity	en_US
dc.subject	Antimicrobial Activities	en_US
dc.subject	Synthesis	en_US
dc.subject	Antimicrobial Hexapeptides	en_US
dc.title	New Antimicrobial Hexapeptides: Synthesis, Antimicrobial Activities, Cytotoxicity, and Mechanistic Studies	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Pharmacy

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