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http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/13859| Title: | New PPARγ ligands based on 2-hydroxy-1,4-naphthoquinone: Computer-aided design, synthesis, and receptor-binding studies |
| Authors: | Sundriyal, Sandeep |
| Keywords: | Pharmacy PPARγ Glitazones Docking Computer-aided drug design Rosiglitazone Farglitazar 2-Hydroxy-1 4-naphthoquinone |
| Issue Date: | Jun-2008 |
| Publisher: | Elsevier |
| Abstract: | FlexX-based molecular docking study was employed to identify 2-hydroxy-1,4-naphthoquinone as a new ‘acidic head group’ for the design of a novel series of PPARγ ligands. To provide the proof of concept, designed molecules were synthesized and evaluated in a standard radioligand-binding assay. Out of eight molecules, four were found to bind to the murine PPARγ with IC50 ranging from 0.2 to 56.2 μM as compared to standard pioglitazone, with IC50 of 0.7 μM |
| URI: | https://www.sciencedirect.com/science/article/pii/S0960894X08004769 http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13859 |
| Appears in Collections: | Department of Pharmacy |
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