New PPARγ ligands based on 2-hydroxy-1,4-naphthoquinone: Computer-aided design, synthesis, and receptor-binding studies

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DC Field	Value	Language
dc.contributor.author	Sundriyal, Sandeep	-
dc.date.accessioned	2024-01-17T07:05:13Z	-
dc.date.available	2024-01-17T07:05:13Z	-
dc.date.issued	2008-06	-
dc.identifier.uri	https://www.sciencedirect.com/science/article/pii/S0960894X08004769	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13859	-
dc.description.abstract	FlexX-based molecular docking study was employed to identify 2-hydroxy-1,4-naphthoquinone as a new ‘acidic head group’ for the design of a novel series of PPARγ ligands. To provide the proof of concept, designed molecules were synthesized and evaluated in a standard radioligand-binding assay. Out of eight molecules, four were found to bind to the murine PPARγ with IC50 ranging from 0.2 to 56.2 μM as compared to standard pioglitazone, with IC50 of 0.7 μM	en_US
dc.language.iso	en	en_US
dc.publisher	Elsevier	en_US
dc.subject	Pharmacy	en_US
dc.subject	PPARγ	en_US
dc.subject	Glitazones	en_US
dc.subject	Docking	en_US
dc.subject	Computer-aided drug design	en_US
dc.subject	Rosiglitazone	en_US
dc.subject	Farglitazar	en_US
dc.subject	2-Hydroxy-1	en_US
dc.subject	4-naphthoquinone	en_US
dc.title	New PPARγ ligands based on 2-hydroxy-1,4-naphthoquinone: Computer-aided design, synthesis, and receptor-binding studies	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Pharmacy

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