Oncostatin M upregulates HIF-1α in breast tumor associated macrophages independent of intracellular oxygen concentration

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DC Field	Value	Language
dc.contributor.author	Shrivastava, Richa	-
dc.date.accessioned	2024-01-19T07:01:25Z	-
dc.date.available	2024-01-19T07:01:25Z	-
dc.date.issued	2018-02	-
dc.identifier.uri	https://www.sciencedirect.com/science/article/pii/S0024320517306550	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13888	-
dc.description.abstract	HIF is an important transcription-regulator for adaptation to cellular stress in cells of myeloid origin. Classically, expression and activity of HIF1-α is regulated by oxygen-concentration within cell. However, there exists an alternative regulatory mechanism affecting HIF1-α levels independent of oxygen concentration particularly in inflammatory cells like macrophages. Here we report the mechanism of HIF1-α upregulation in TAMs by Oncostatin-M (OSM) independent of cellular oxygen concentration.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsevier	en_US
dc.subject	Pharmacy	en_US
dc.subject	TAMs	en_US
dc.subject	Oncostatin M	en_US
dc.subject	HIF-1α	en_US
dc.subject	Normoxia	en_US
dc.subject	M2 macrophages	en_US
dc.title	Oncostatin M upregulates HIF-1α in breast tumor associated macrophages independent of intracellular oxygen concentration	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Pharmacy

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