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http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/13891| Title: | AzaGly-Appended Peptidomimetics Structurally Related to PTR6154 as Potential PKB/Akt Inhibitors |
| Authors: | Shrivastava, Richa |
| Keywords: | Pharmacy Peptidomimetics PKB/Akt Inhibitors |
| Issue Date: | Apr-2017 |
| Publisher: | Wiley |
| Abstract: | Synthesis of AzaGly-appended peptidomimetics with improved biological and biochemical properties. Robust synthesis of azapeptide on solid support is demonstrated without noticeable hydantoin formation. The azapeptide derived from the GSK-3β substrate exhibited improved properties in terms of Akt kinase inhibitory activity and basal degradation, proteolytic degradation, conformation and binding affinities. |
| URI: | https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201700031 http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13891 |
| Appears in Collections: | Department of Pharmacy |
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