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Title: | Investigation of the Reactivity of 1-Azido-3-iodobicyclo[1.1.1]pentane under “Click” Reaction Conditions |
Authors: | Grover, Nitika |
Keywords: | Chemistry Addition reactions Beverages Column chromatography Mixtures |
Issue Date: | Dec-2020 |
Publisher: | ACS |
Abstract: | The bicyclo[1.1.1]pentane (BCP) unit is under scrutiny as a bioisostere in drug molecules. We employed methodologies for the synthesis of different BCP triazole building blocks from one precursor, 1-azido-3-iodobicyclo[1.1.1]pentane, by “click” reactions and integrated cycloaddition–Sonogashira coupling reactions. Thereby, we accessed 1,4-disubstituted triazoles, 5-iodo-1,4,5-trisubstituted triazoles, and 5-alkynylated 1,4,5-trisubstituted triazoles. This gives entry to the synthesis of multiply substituted BCP triazoles on either a modular or a one-pot basis. These methodologies were further utilized for appending porphyrin moieties onto the BCP core. |
URI: | https://pubs.acs.org/doi/10.1021/acs.joc.0c02432 http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15185 |
Appears in Collections: | Department of Chemistry |
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