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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Grover, Nitika | - |
dc.date.accessioned | 2024-08-10T04:25:28Z | - |
dc.date.available | 2024-08-10T04:25:28Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.uri | https://pubs.acs.org/doi/10.1021/acs.joc.0c02432 | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15185 | - |
dc.description.abstract | The bicyclo[1.1.1]pentane (BCP) unit is under scrutiny as a bioisostere in drug molecules. We employed methodologies for the synthesis of different BCP triazole building blocks from one precursor, 1-azido-3-iodobicyclo[1.1.1]pentane, by “click” reactions and integrated cycloaddition–Sonogashira coupling reactions. Thereby, we accessed 1,4-disubstituted triazoles, 5-iodo-1,4,5-trisubstituted triazoles, and 5-alkynylated 1,4,5-trisubstituted triazoles. This gives entry to the synthesis of multiply substituted BCP triazoles on either a modular or a one-pot basis. These methodologies were further utilized for appending porphyrin moieties onto the BCP core. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ACS | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Addition reactions | en_US |
dc.subject | Beverages | en_US |
dc.subject | Column chromatography | en_US |
dc.subject | Mixtures | en_US |
dc.title | Investigation of the Reactivity of 1-Azido-3-iodobicyclo[1.1.1]pentane under “Click” Reaction Conditions | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Chemistry |
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